Ces Urol 2008, 12(1):31-36 | DOI: 10.48095/cccu2008005

Prediction of the prostate cancer pathological classification

Otakar Čapoun, Marek Babjuk, Jan Dvořáček, Tomáš Hanuš, Libor Šafařík, Ivan Pavlík

Urologická klinika 1. LF UK a VFN, Praha

Aim:
We performed a retrospective analysis of pre-operative parameters in patients with prostate cancer (CaP) and assessed the risk of the locally advanced carcinoma after radical prostatectomy.

Material and methods:
Between years 2000 and 2006, 471 men with clinically organ confined CaP underwent radical prostatectomy (RP). All standard preoperative parameters were collected preoperatively Pathological stage and Gleason score (GS), as well as surgical margin status and perineural invasion in the surgical specimen were registered. An impact of the preoperative parameters on the pT stage was assessed by Spearman rank correlation coefficient method. Statistical significance was defined as p < 0.05.

Results:
The mean age was 62 years, the mean initial prostate specific antigen (PSA) level was 10.55 ng/ml, with cTlc stage presented 67.2 % men. The organ confined disease after RP was found in 72.9 % patiens, surgical GS higher than six was identified in 20,3 % cases. Positive surgical margin and perineural invasion was described in 12,7 % and 46,3 % specimen, respectively. All investigated preoperative parameters were found to have an impact on the pathological stage of prostate cancer.

Conclusion:
All standard preoperative parameters were statistically significant, with the highest risk of pT3 cancer for patients with the bioptical GS higher than seven, positive digital rectal examination and/or preoperative PSA level higher than 10 ng/ml.

Keywords: prostate cancer, radical prostatectomy

Received: May 17, 2008; Accepted: June 25, 2008; Published: January 1, 2008