Ces Urol 2017, 21(4):299-304 | DOI: 10.48095/cccu2017040

A solitary skeletal metastasis in the thumb of a silent bilateral clear cell renal cell carcinoma pT1a in a patient with a sporadic uro‑oncological triplicity

Jan Novák¹, Lukáš Fišer¹, Robert Jůzek², Jan Lesenský², Jan Pertlíček³, Zuzana Špůrková⁴, Petra Beroušková⁵, Lubomír Hyršl¹

¹ Urologické oddělení, Oblastní nemocnice Kladno, a. s., Kladno

² Ortopedická klinika, 1. LF UK a Nemocnice Na Bulovce, Praha

³ Chirurgické oddělení, Oblastní nemocnice Kladno, a. s., Kladno

⁴ Patologicko‑anatomické oddělení, Nemocnice Na Bulovce, Praha

⁵ Patologicko‑anatomické oddělení, Oblastní nemocnice Kladno, a. s., Kladno

Novák J, Fišer L, Jůzek R, Lesenský J, Pertlíček J, Špůrková Z, Beroušková P, Hyršl L. A solitary skeletal metastasis in the thumb of a silent bilateral clear cell renal cell carcinoma pT1a in a patient with a sporadic uro-oncological triplicity. We present a case report of a 72-year old male with a long urological history (prostate adenocarcinoma after radical prostatectomy with rising PSA level and urothelial carcinoma pTa low grade with one recurrence) who underwent reconstructive surgery for a left thumb metastasis of a clear cell renal cell carcinoma. Repeated CT scans showed two tiny lesions in both kidneys during follow-up. Nephron-sparing surgery of the right kidney and left-sided nephroureterectomy in two sessions proved a bilateral clear cell renal cell carcinoma pT1a. The patient underwent genetic analysis by the sequence capture panel CZECANCA targeting 219 susceptibility genes to reveal a highly presumable hereditary cancer syndrome, but no significant mutation was found.

Keywords: Solitary skeletal metastasis, bilateral kidney cancer, clear cell renal cell carcinoma pT1a, uro-oncological triplicity.

Received: September 11, 2017; Accepted: November 13, 2017; Published: December 19, 2017