Ces Urol X:X | DOI: 10.48095/cccu2025018

Histological findings in a completely duplicated kidney and ureter after heminephrectomy

Martina Košudová¹, Minh Nguyet Tranová², Pavel Navrátil^2,3, Miroslav Podhola⁴, Ivo Novák²

¹ Urologie, Nemocnice Havířov

² Urologická klinika, FN Hradec Králové

³ LF UK, FN Hradec Králové

⁴ Fingerlandův ústav patologie, FN Hradec Králové

Introduction: Complete duplication of the kidney and ureter is a common congenital anomaly of the urinary tract, often associated with ectopic ureter, ureterocele, or vesicoureteral reflux. In cases of severe hypofunction of the upper moiety, heminephrectomy is indicated.

Objective: The aim of this study was to analyze the histopathological findings in resected upper segments of completely duplicated kidneys in pediatric patients undergoing heminephrectomy.

Methods: A retrospective analysis was conducted on 26 children operated on between 2000 and 2024 for complete duplication of the upper urinary tract at the University Hospital Hradec Králové. Clinical data and histological findings were evaluated.

Results: The most frequent findings were chronic inflammatory changes (77%) and renal dysplasia (46%), more commonly associated with ectopic ureter than ureterocele. Additional findings included tubular atrophy, interstitial fibrosis, glomerulosclerosis, and urothelial metaplasia in one case.

Conclusion: Histopathological changes in the upper moiety of completely duplicated kidneys reflect a combination of congenital and secondary damage, resulting in irreversible loss of segmental function. Heminephrectomy is an effective therapeutic method, and histological analysis contributes to a better understanding of the pathogenesis of these conditions.

Keywords: pediatric urology – heminephrectomy – histopathology – duplicated kidney

Received: June 11, 2025; Revised: July 18, 2025; Accepted: August 12, 2025; Prepublished online: September 4, 2025