Ces Urol 2012, 16(2):83-91 | DOI: 10.48095/cccu2012015

Failure of local treatment of prostate cancer

Milan Král, Vladimír Študent

Urologická klinika LF UP a FN, Olomouc

Terapeutic options with curative intent in prostate cancer include radical prostatectomy and radiotherapy. In many patients, rising PSA after completing the local therapy is detected and this is a marker of disease persistence. This PSA increase is often the only evidence of cancer relaps which usually preceeds clinical manifestation by months or years. Based on parameters such time to biochemical relaps, PSA kinetics, clinical or even patological features (staging, grading), the physician has to differ, whether local or systemic relaps occurs. Regarding to the type of relaps, further treatment is indicated.

Keywords: prostate cancer, therapy failure, salvage therapy, PSA

Received: February 2, 2012; Accepted: March 30, 2012; Published: March 1, 2012