Ces Urol 2017, 21(4):272-279 | DOI: 10.48095/cccu2017045

Lynch syndrome in the hands of the urologist

Tomáš Pitra¹, Kristýna Pivovarčíková², Hana Sedláčková¹, Ondřej Hes², Milan Hora¹, Ondřej Daum²

¹ Urologická klinika LF UK a FN Plzeň

² Šiklův ústav patologie LF UK a FN Plzeň

Pitra T, Pivovarčíková K, Sedláčková H, Hes O, Hora M, Daum O. Lynch syndrome in the hands of the urologist. Major statement: Review dealing with Lynch syndrome, its presentation, diagnosis, treatment and surveillance in the urinary tract. Lynch syndrome (LS) is an inherited autosomal dominant cancer syndrome. It presents in young/middle aged patients and it predisposes individuals to wide spectrum of malignancies in different organs (the most frequent are tumors of colon and endomemetrium). LS is typically associated with upper urinary tract urothelial carcinoma (UUTUC), which is considered to be the third most frequent tumor in LS. Recently, a large number of papers have been published calling for the determination of optimal strategies in screening, detection, surveillance and management of patients with LS. Despite this clear association between UUTUC and LS, there are no well-defined strategies in common use, which can be routinely applied in clinical practice. At present, the most effective and safe surveillance protocols are unknown.

Keywords: Lynch syndrome, hereditary disease, urothelial carcinoma, upper urinary tract.

Received: November 1, 2017; Accepted: November 27, 2017; Prepublished online: December 8, 2017; Published: December 19, 2017