Ces Urol 2007, 11(3):82-86 | DOI: 10.48095/cccu2007017

Predictive nomogram for Gleason score up-grading after prostate biopsy

M. Král, V. Študent, A. Vidlář, M. Hrabec, D. Marek

Urologická klinika LF UP a FN, Olomouc

Introduction: The aim of our study was to compare Gleason score in biopsy and after radical prostatectomy to form a mathematical model for more accurate prediction of carcinoma grading after prostatectomy already from initial biopsy.

Material and methods: our group included 159 patients after radical prostatectomy at our institution. We perform reevaluation of bioptic and postoperative specimens according to new recommendation of pathologists.

Results: in biopsies there were 46,4% specimens included into intermediate grade and 53,5% specimens included into high grade cancers while after prostatectomy there were only 21,3% intermediate grade and 78,6% high grade cancers. From these Gleason scores shifts afterward we formed a predictive table.

Conclusion: we approved quite evident histologie evaluation improvement and higher correlation between bioptic and postoperative findings. Thus we can predict expectable Gleason score already from biopsy and incorporate this finding into decision making algorithm in prostate cancer therapy.

Keywords: prostate cancer, Gleason score, correlation, nomogram, biopsy, radical prostatectomy

Published: June 1, 2007