Ces Urol 2001, 5(1):13-16 | DOI: 10.48095/cccu2001003

Our first experiences with photodynamic diagnostics of superficial tumours of the urinary bladder

J. Kočárek, O. Kőhler, O. Bernard, J. Poduška, M. Bartůněk, P. Drlík

Urologické oddělení Ústřední vojenské nemocnice Praha

Authors present their first experiences with photodynamic diagnostics of the superficial tumours of the urinary bladder (PDD).
In the time period from June 1999 till September 2000, the endoscopic examination using fluorescence induced by intravesical instillation of 5-aminolevulic acid solution was provided in 23 patients with suspected urinary bladder tumour. All patients had intermittent microscopic haematuria and suspected or positive results of urine cytology (PAP lll-IV) together with normal urogram findings and no tumour was identified by cystoscopic evaluation in pure light.
Although the cystoscopic evaluation in pure light gave negative results, the photo-dynamic diagnostics followed by targeted biopsy of the fluorescent focus identified 3 cases of severe urothel dysplasia, 1 case of carcinoma in situ (TIS), 3 cases of urinary bladder tumour Ta and lease of T1. We did not observed any adverse effects following the intravesical application of 3% solution of 5-aminolevulic acid (5-ALA).

Keywords: Superficial bladder tumor, Fluorescency, Photodynamic endoscopy 5-aminolevulinic acid, Protoporfyrin IX

Published: January 1, 2001