Ces Urol 2006, 10(1):5-9 | DOI: 10.48095/cccu2006002

p53 and Ki 67 expression in patients with localized conventional renal cell carcinoma

M. Babjuk¹, J. Dušková², J. Stolz¹, V. Soukup¹, J. Mareš³, T. Viktorova³, P. Macek¹, L. Pecen⁴, I. Pavlík¹, J. Dvořáček¹

¹ Urologická klinika Všeobecné fakultní nemocnice a 1. LF UK, Katedra urologie IPVZ, Praha

² Ústav patologie Všeobecné fakultní nemocnice a 1. LF UK, Katedra patologie IPVZ, Praha

³ Ústav biologie a lékařské genetiky, FN Motol, Praha

⁴ Ústav informatiky, Akademie věd ČR, Praha

Introduction: The aim was to assess the presence of p53 and Ki 67 expression in patients with localized conventional (clear cell) renal cell carcinoma.

Material and methods: Seventy patients with stage pT1 and pT2 conventional (clear cell) renal cell carcinoma were included in the study. Nephrectomy was performed in 58 patients and renal resection in 12. Expression of p53 a Ki 67 was detected in both cancerous and non-cancerous tissues of the kidney. Immunohistochemistry results were evaluated semiquantitatively using HSCORE. During a mean follow-up of 21 months tumour recurrence occurred in 8 patients.

Results: Expression of p53 in tumour tissue was present in 65% and expression of Ki 67 in 96% of patients. The quantity of expression of both proteins was significantly higher in cancerous tissue as compared to non-cancerous tissue. The quantity of p53 expression in the tumour did not correlate with the clinical-pathological factors nor with the course of the disease. The quantity of Ki 67 expression in the cancerous tissue increased accordingly with the tumour grade and was somewhat related to the further course of the disease, this influence, however, was not statistically significant. The high level of Ki 67 expression in the non-cancerous tissue correlated significantly with the risk of disease recurrence.

Conclusion: Expression of p53 and Ki 67 in the cancerous tissue can be detected in a high proportion of patients with localized conventional renal cell carcinoma.

Keywords: localized conventional (clear cell) renal cell carcinoma, tumour recurrence, immunohistochemistry test, p53- Ki 67

Published: January 1, 2006